Gene information
Official symbol MIR221
Official full name microRNA 221
Gene type microRNA
ChromosomeXp11.3
Alias symbolhsa-mir-221
Previous symbolMIRN221
Gene familyMicroRNAs
Resources
Entrez Gene 407006
HGNC HGNC:31601
Ensembl ENSG00000207870
UCSC uc011mle.1
GO terms: 118 records
GO Description Category LogP Number of genes Detail
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0003729 mRNA binding GO Molecular Functions -83.3296105 82 More
GO:0006417 regulation of translation GO Biological Processes -24.5257987 35 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007346 regulation of mitotic cell cycle GO Biological Processes -10.6017433 22 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009743 response to carbohydrate GO Biological Processes -20.6536066 44 More
GO:0009746 response to hexose GO Biological Processes -16.2230361 35 More
GO:0009749 response to glucose GO Biological Processes -15.7538948 34 More
GO:0010564 regulation of cell cycle process GO Biological Processes -6.45429517 20 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010595 positive regulation of endothelial cell migration GO Biological Processes -28.3201829 45 More
GO:0010596 negative regulation of endothelial cell migration GO Biological Processes -31.4991544 25 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010633 negative regulation of epithelial cell migration GO Biological Processes -29.7632977 25 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0010717 regulation of epithelial to mesenchymal transition GO Biological Processes -12.1292389 25 More
GO:0010939 regulation of necrotic cell death GO Biological Processes -7.38163620 7 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010975 regulation of neuron projection development GO Biological Processes -5.89330331 41 More
GO:0010976 positive regulation of neuron projection development GO Biological Processes -4.13061709 18 More
GO:0014910 regulation of smooth muscle cell migration GO Biological Processes -16.4082106 27 More
GO:0014911 positive regulation of smooth muscle cell migration GO Biological Processes -11.1068742 16 More
GO:0016441 post-transcriptional gene silencing GO Biological Processes -100 124 More
GO:0016525 negative regulation of angiogenesis GO Biological Processes -31.9326641 51 More
GO:0017148 negative regulation of translation GO Biological Processes -31.7864246 33 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030336 negative regulation of cell migration GO Biological Processes -30.9008082 37 More
GO:0030371 translation repressor activity GO Molecular Functions -100 82 More
GO:0031047 gene silencing by RNA GO Biological Processes -100 125 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031346 positive regulation of cell projection organization GO Biological Processes -6.78114948 37 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0034248 regulation of cellular amide metabolic process GO Biological Processes -28.1662419 40 More
GO:0034249 negative regulation of cellular amide metabolic process GO Biological Processes -35.7644618 37 More
GO:0034284 response to monosaccharide GO Biological Processes -18.9205843 39 More
GO:0035194 post-transcriptional gene silencing by RNA GO Biological Processes -100 124 More
GO:0035195 miRNA-mediated gene silencing GO Biological Processes -100 124 More
GO:0035278 miRNA-mediated gene silencing by inhibition of translation GO Biological Processes -46.1099674 32 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043409 negative regulation of MAPK cascade GO Biological Processes -13.5471736 35 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043535 regulation of blood vessel endothelial cell migration GO Biological Processes -45.8916712 37 More
GO:0043536 positive regulation of blood vessel endothelial cell migration GO Biological Processes -25.0316183 33 More
GO:0043537 negative regulation of blood vessel endothelial cell migration GO Biological Processes -32.3610392 24 More
GO:0045182 translation regulator activity GO Molecular Functions -97.0300828 82 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045931 positive regulation of mitotic cell cycle GO Biological Processes -2.62838915 5 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0051052 regulation of DNA metabolic process GO Biological Processes -4.01973325 42 More
GO:0051147 regulation of muscle cell differentiation GO Biological Processes -17.2781401 19 More
GO:0051148 negative regulation of muscle cell differentiation GO Biological Processes -3.93077688 11 More
GO:0051150 regulation of smooth muscle cell differentiation GO Biological Processes -12.3730388 10 More
GO:0051151 negative regulation of smooth muscle cell differentiation GO Biological Processes -3.30457530 3 More
GO:0051271 negative regulation of cellular component movement GO Biological Processes -29.9238399 37 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060547 negative regulation of necrotic cell death GO Biological Processes -6.08298027 5 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070373 negative regulation of ERK1 and ERK2 cascade GO Biological Processes -5.87762530 7 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0072091 regulation of stem cell proliferation GO Biological Processes -6.89052200 13 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0090049 regulation of cell migration involved in sprouting angiogenesis GO Biological Processes -34.2220297 25 More
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis GO Biological Processes -23.4562080 16 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:1900015 regulation of cytokine production involved in inflammatory response GO Biological Processes -18.8349263 16 More
GO:1900016 negative regulation of cytokine production involved in inflammatory response GO Biological Processes -7.97228906 7 More
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle GO Biological Processes -4.34225844 5 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901343 negative regulation of vasculature development GO Biological Processes -32.5354692 52 More
GO:1901987 regulation of cell cycle phase transition GO Biological Processes -7.48321149 17 More
GO:1901989 positive regulation of cell cycle phase transition GO Biological Processes -2.70322984 5 More
GO:1901990 regulation of mitotic cell cycle phase transition GO Biological Processes -9.06841215 17 More
GO:1901992 positive regulation of mitotic cell cycle phase transition GO Biological Processes -3.09980086 5 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1902806 regulation of cell cycle G1/S phase transition GO Biological Processes -9.32363308 14 More
GO:1902808 positive regulation of cell cycle G1/S phase transition GO Biological Processes -3.89819595 5 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903038 negative regulation of leukocyte cell-cell adhesion GO Biological Processes -10.2281373 27 More
GO:1903231 mRNA base-pairing post-transcriptional repressor activity GO Molecular Functions -100 82 More
GO:1903670 regulation of sprouting angiogenesis GO Biological Processes -15.4916023 13 More
GO:1903671 negative regulation of sprouting angiogenesis GO Biological Processes -10.7977241 8 More
GO:1903975 regulation of glial cell migration GO Biological Processes -5.72938190 7 More
GO:1903977 positive regulation of glial cell migration GO Biological Processes -7.18867136 7 More
GO:1904705 regulation of vascular associated smooth muscle cell proliferation GO Biological Processes -22.4951686 19 More
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation GO Biological Processes -15.2818318 12 More
GO:1904752 regulation of vascular associated smooth muscle cell migration GO Biological Processes -12.1572954 10 More
GO:1904754 positive regulation of vascular associated smooth muscle cell migration GO Biological Processes -6.48970377 5 More
GO:1904892 regulation of receptor signaling pathway via STAT GO Biological Processes -12.9980471 24 More
GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell GO Biological Processes -9.55155535 14 More
GO:1905063 regulation of vascular associated smooth muscle cell differentiation GO Biological Processes -11.0911570 8 More
GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation GO Biological Processes -4.01518900 3 More
GO:2000045 regulation of G1/S transition of mitotic cell cycle GO Biological Processes -10.1341432 14 More
GO:2000112 regulation of cellular macromolecule biosynthetic process GO Biological Processes -24.0725356 37 More
GO:2000113 negative regulation of cellular macromolecule biosynthetic process GO Biological Processes -32.997895 35 More
GO:2000146 negative regulation of cell motility GO Biological Processes -30.256132 37 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000181 negative regulation of blood vessel morphogenesis GO Biological Processes -32.6997315 52 More
GO:2000647 negative regulation of stem cell proliferation GO Biological Processes -4.56141436 5 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa05206 MicroRNAs in cancer KEGG Pathway -100 81 More
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
hsa-miR-221-3p transcriptomics good predictor acute myocardial infarction[diagnosis] acute myocardial infarction Coskunpinar E et al. Gene. 2016
All rights reserved: Soochow University Center for Systems Biology